Menopause-related depression, long under-researched and undertreated, now meets innovation in brain stimulation therapy. A recent pilot study demonstrates that this technology provides relief across mood, sleep, and cognitive symptoms, underscoring the urgent need for accessible, holistic treatments.
For many women, the menopause transition brings not only physical changes but profound mental health challenges—depression, anxiety, and cognitive fog among them. Unfortunately, this vulnerable group has often been overlooked in research and treatment development. Now, a groundbreaking pilot study conducted by Flow Neuroscience and The House of Hormones (THOH) offers encouraging evidence that brain stimulation therapy, delivered conveniently at home, can significantly improve mood, sleep, and daily functioning for perimenopausal and menopausal women.
Addressing an Understudied Crisis
Women navigating menopause are up to 40% more likely to experience depression than those without menopausal symptoms. As psychologist Leah Christian, CEO of THOH, emphasises, “Women’s health has long been under-researched, underfunded, and under-prioritised. This study is a breakthrough for our community, offering a path to reclaim their well-being well before reaching crisis.”
Over ten weeks, participants using Flow’s brain stimulation headset reported a 30% reduction in depressive symptoms and anxiety, accompanied by up to a 46% improvement in sleep quality and daily functioning. These improvements were seen as early as Week 4 and grew by Week 10 to encompass better relationships and enhanced brain clarity.
The Science Behind Brain Stimulation
Dr Hannah Nearney, UK Medical Director at Flow Neuroscience, highlights the complexity of menopausal depression: “It’s never just low mood. Depression during this time affects sleep, cognition, relationships, and quality of life. Current treatments often focus narrowly, sometimes worsening side effects already experienced.”
Brain stimulation, she explains, offers a holistic alternative. By targeting the brain’s mood and cognitive networks non-invasively, this therapy helps relieve a broad spectrum of symptoms including mood decline, insomnia, irritability, and daily functioning challenges—without the side effects typical of many antidepressants.
Real Impact on Women’s Lives
For 63-year-old Caroline Kay, a study participant, the therapy was transformative: “It lowered my feelings of uselessness and irritability. I found new patience and rediscovered my usual easy-going nature.” Such testimonials underscore the promise of this technology in restoring not just health, but identity and connection.
Safety was also reassuring. No severe side effects occurred; mild tingling was the only complaint. With 91% willing to continue use and 82% recommending it, the device proves both effective and well-tolerated.
A Vision for Accessible Care
Erin Lee (above), CEO of Flow Neuroscience, summarises the significance: “Women deserve treatment that fits their lives — a one-stop, side effect–free option tackling the complex challenges of menopause-related depression.” With prior studies affirming its effectiveness, Flow’s device is now clinically proven and available in multiple countries, marking a shift in how midlife women approach their mental health.
Looking Ahead
While this pilot represents a hopeful step, larger trials are necessary to confirm the findings and expand access. Yet for women in menopause, often underserved in mental health care, brain stimulation therapy may soon provide a powerful, science-backed beacon of relief—restoring mood, cognition, and daily vitality.
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